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22nd American Peptide Symposium - June 25-30, 2011; San Diego, California, USA
- Amino acid basics - a well done Flash animation on amino acids, peptide synthesis, and secondary structure
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Amino acid overview
- a basic reference covering the structure and chemical properties of
amino acids. Individual amino acids and other terms are hyperlinked to
more in depth descriptions.
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Amino acid properties
- a good references page describing general properties (e.g.,
structures and protecting group masses), suggested amino acid
substitutions, chemical properties (e.g., chemical classification and
hydrophobicity), structural properties (e.g., peptide bond angles and
Chou-Fasman parameters), and genetic properties. Original references
for all the tables are also provided. From PROWL - a resource for protein chemistry and mass spectrometry.
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Bioactive Polypeptide Database
- a database that contains three sections to find a bioactive peptide
by peptide sequence, gene sequence, or a reference search
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Biosynthesis of amino acids
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Botany Online: Basic Metabolism
- choose your amino acid, its metabolism or degradation, and your
organism to view complete metabolic pathways. The front page comes with
a great overview of plant amino acid metabolism.
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Bruce Merrifield - a brief biography - the father of solid phase peptide chemistry
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A de novo peptide sequencing tutorial
- a informative website devoted to how to interpret mass spectrometry
fragmentation for the purpose of peptide identification. There is a
useful glossary explaining terms like b and y ions, example spectra,
helpful references, and tables of amino acid masses, dipeptide masses,
and possible conflicting masses.
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How Does Mass Spectrometry Identify Proteins?
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The Medical Biochemistry Page
- a page with a variety of topics related to the title including amino
acid metabolism, specialized products of amino acids, and the basic
chemistry of biomolecules.
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Molecular Expressions: The Amino Acid Collection
- an overview of some of the interesting roles and properties of the
20+ naturally occuring amino acids. Each is accompanied by a groovy
picture.
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Nomenclature and Symbolism for Amino Acids and Peptides - from the International Union of Pure and Applied Chemistry and the International Union of Biochemistry and Molecular Biology.
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Peptide Antigen Database - from the Protein Lounge.
This database contains antigenic peptide targets against all known
protein sequences throughout a variety of organisms. All peptide
targets are linked to the Protein lounge online hydroplotting tool,
which allows you to view an interactive version of the protein sequence
on a hydrophilicity/hydrophobicity plot.
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Peptide Hormones
- a colorful reference containing data on the title subject such as a
descriptive table of peptide hormones, the structure and function of
hormones, and detailed information on the function of specific peptide
hormones (e.g. vasopressin and oxytocin, natriuretic hormone,
calcitonin, etc...).
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Peptide Sequencing and Synthesis - a mechanistic overview of Edmand degradation and DCC coupling
- Peptides as Drugs: Discovery and Development - a market report
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Protein Synthesis - an overview
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Peptide Synthesis Tips and Procedures - from EMD.
A series of very informative brochures (downloadable as PDF files) on
such areas as coupling protocols, the synthesis of long or difficult to
synthesize peptides, loading and cleavage protocols, peptide ligation
and labeling, and much more. This is an interesting place to visit if
you are into the chemistry of solid phase peptide synthesis.
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Proteins, peptides, and amino acids
- a nicely illustrated and descriptive overview which covers: α-Amino
Acids, Reactions of Amino Acids, Synthesis of Amino Acids, Peptides
& Proteins, The Primary Structure of Peptides, Secondary &
Tertiary Structure of Large Peptides and Proteins, and Peptide
Synthesis
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Signal Peptide Database (SPdb)
- a database of experimentally verified signal peptides. Amongst other
criteria, the authors compiled the sequences by extracting entries from
Swiss-Prot that contained the key work "signal" in the feature table.
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Stanley Miller - two webistes on his classic experiment on the abiotic and primordial synthesis of amino acids: #1 and #2
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thinkpeptides
- a website with a technical support section covering such topics as
peptide design, solubility, and purity issues, as well as peptides for
anti-sera production and peptide library design
