Suppliers of peptide
synthesis reagents and peptides
Since Bruce
Merrifield's
first solid phase synthesis of a peptide, peptides have become readily
available tools for the biologist, biochemist, and chemist. If you are
involved in the synthesis
of peptides or peptidomimetics,
(click on the link for a great reference book), this webpage can guide
you to suppliers of peptide synthesis reagents and starting materials.
If
you are interested in pre-made peptides, you can also use this webpage
to find vendors who sell biologically active peptides and peptide
substrates. Please use these codes to find companies that sell the
following reagents:
-
amino acids (AA
or UAA)
- divided up into two categories: naturally occurring amino acids (AA)
or unnatural amino acids (UAA), usually protected with a protecting
group suitable for Fmoc peptide synthesis. Unnatural amino acids
include D-amino acids, alpha amino acids with non-natural side chains,
beta amino acids, gamma amino acids, etc...
-
peptide synthesis reagents (reagents)
- this category can include peptide coupling reagents (EDC, HBTU, HOBt,
etc...) and peptide synthesis grade solvents
-
peptides (peptides)
- includes bioactive peptides, antimicrobial peptides, and
chromogenic/fluorogenic peptide substrates
- resins (resins)
- for solid phase peptide (SPPS) and organic synthesis (SPOS)
If
you know of a company that should be added or deleted from this section
or if you would like to update your company description, please email us. Finally, don't forget to
see our Peptide Fun Fact
below!
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AAPPTec
- (AA, UAA, reagents, resins)
- including pre-weighed amino acids for solid phase peptide synthesis,
coupling reagents, and AM SURE™ = Aminomethyl Surface-Layered
Polysytrene Resin
-
AbCam
- (peptides) - over 4000 peptides are available from
their online catalog
-
ACES
Pharma - (AA, UAA, peptides) - Z protected
and N-methyl amino acids
-
Advanced
ChemTech - (AA, UAA, peptides, reagents, resins)
-
Advanced
Targeting Systems - (peptides)
-
Affinity
Bioreagents (Thermo Scientific) - (peptides)
-
AGTC
Bioproducts - (AA, UAA, reagents, resins)
-
American
Peptide Company - (AA, resins) - loaded
amino acid resins
-
American
Bioanalytical - (reagents) - ultrapure
solvents for peptide synthesis
-
Anaspec
- (AA, UAA, peptides, reagents, resins)
-
Applied
Biosystems - (reagents, resins)
-
Auspep
- (AA, peptides, reagents, resins)
-
Bachem
- (AA, UAA, peptides, reagents, resins)
- a large supplier with more than 9000 products in stock. For a video
overview of their services, click here.
-
Bharavi
Laboratories - (UAA, resins) - unusual
amino acids, pre-loaded resins, and resins for organic synthesis
-
Biomer
Technology - (peptides)
- Biopeptek
-
Biopeptide
- (peptides) -
beta-amyloid (including deuterated versions) and ghrelin peptides
-
Bio-Synthesis
- (peptides) - including cosmetic peptides
-
Bratox
- (peptides) - a Brazilian distributor of peptide
snake venom toxins and reagents useful for antibody manufacturing
-
California
Peptide Research - (peptides)
- Cambridge
Research Biochemicals - (peptides, reagents)
- makers of bioactive and stable labeled peptides, PNA monomers, and
fluorescent dyes including the CHROMIS product line. Try
their dye-selection
tool to find the fluorophore best suited to label your
peptide.
-
Cambridge
Isotope Laboratories - (UAA) - stable
isotope labeled amino acids including unnatural amino acids and Fmoc
and t-BOC derivatized amino acids
-
Carbomer
- (peptides) - polyamino acids
-
CBL
Biopharma - (AA, UAA, peptides, resins) -
including N-α-Trt-amino acids
-
Cell
Sciences - (peptides)
-
CenterChem
- (peptides) - chromogenic and fluorogenic peptide
substrates for serine proteases
-
ChemPep
- (AA, peptides, reagents, resins)
- a manufacturer and supplier of resins and peptide synthesis reagents
(Fmoc, Boc protected amino acids, coupling reagents and protecting
reagents)
-
Chengdu
Chempep New Technology - (AA, UAA, reagents)
- Chengdu
CP Biochem Company - (AA, UAA,
peptides) - cosmetic and API peptides from gram to
kilogram scales
- CHI
Scientific - (AA, UAA, peptides, reagents,
resins)
-
CPC
Scientific - (AA, UAA, peptides, reagents, resins)
- Creative
Peptides - (peptides) - research
and cosmetic peptides
-
CS
Bio - (AA, UAA, peptides, resins)
-
CSPS
Pharmaceuticals - (AA, UAA, resins) -
supplier of safety catch resins
-
Designer
BioScience - (AA, peptides, reagents, resins)
- EMD
Chemcials (EMD4 Biosciences) - (AA, UAA, peptides,
reagents,
resins) - reagents for solid phase organic chemistry as well
-
Feldan-Bio
- (peptides)
- chemokines, cytokines, growth factors, and hormones
-
GeneTex
- (peptides) - over 400 peptides
-
GL
Biochem - (AA, UAA, peptides, reagents, resins)

Peptide
Fun Fact: The first synthetic
peptide (Gly-Gly) was produced by Emil
Fischer
in 1901 using unprotected amino acids [Ber. Dtsch. Chem. Ges. 34 (1901)
2868]. With the development of N-protected amino acids and
methods to activate them for amide bond formation, the complexity of
synthesized peptide targets increased. In 1953 Vincent
du Vigneaud completed the total synthesis of the cyclic
peptide oxytocin [J.
Am. Chem. Soc. 76
(1954) 3115]. This effort was undertaken to
characterize the structure of this hormone and led to his winning of
the 1955
Nobel Prize in Chemistry.
Another significant synthetic milestone in the history of biologically
active peptides was the total synthesis of the enzyme ribonuclease A in
1969 by Gutte and Merrifield
[J.
Am. Chem. Soc. 91 (1969) 501].
This 124 residue enzyme was produced via solid phase synthesis using
Boc protected amino acids and dicyclohexy!carbodiimide (DCC) in an
overall yield of 17%. The work of Fischer, Vignead, and Merrifield
helped lay the groundwork for our current ability to produce
pharmaceutically active peptides on the kilogram scale.

-
Hande
Sciences - (UAA) - Boc, Fmoc, and Cbz
protected unnatural amino acids
-
Hanhong
Chemical - (AA, UAA, reagents, resins) - a
Chinese manufacturer of protected amino acids, reagents, and peptides
-
HM-Chemo
- (UAA) - from gram to bulk quantities. They also do
custom amino acid synthesis.
-
INBIOS
- (AA, UAA, reagents) - glycosylated amino acids for
Fmoc synthesis
-
IRIS
Biotech - (AA, UAA, reagents, resins) -
reagents are sold in gram to multi-ton lots
- Invitrogen
-
blocking peptides and neuropeptides (used to be Biosource)
-
LC
Sciences - (AA, UAA, reagents, resins) -
including the L and D forms of Boc and Fmoc protected amino acids
-
Luxembourg
Bio Technologies - (AA, UAA, peptides, reagents)
- makers of COMU ([(1-(cyano-2-ethoxy-2-oxoethylideneaminooxy)-
dimethylamino-morpholino)] uronium hexafluorophosphate) which they
promote as a safer alternative
to HATU
for industrial applications. They also sell Oxymure which is
described as the most effective racemization suppressing coupling
additive, bi-functional amino acid derivatives, and dipeptides.
-
Midwest
Bio-Tech - (AA, UAA, peptides, reagents, resins)
-
Mimotopes - (AA,
UAA, peptides, reagents, resins)
- makers of SynPhase™ Lantern - a resin alternative for solid phase
synthesis. The cylindrical solid phase product is a mobile surface
polymer grafted onto a rigid unreactive base polymer.
- Neuland
Laboratories -
(AA, UAA) - Fmoc amino acids, isoacyl
dipeptides, and pseudoproline dipeptides
-
New
England Peptides - (AA, UAA, reagents, resins)
- Ningbo
Hi-techbiochemicals - (AA, UAA, peptides)
- cosmetic peptides and protected amino acids
-
Novus
Biologicals - (peptides)
-
Omegachem
- (UAA)
-
ORPEGEN
- (AA, UAA, peptides, resins, reagents)
- including Ddz and Cbz protected amino acids
-
Peprotech
- (peptides) - specializing in growth factors and
cytokines
-
Pentabiotech
- (peptides, AA, UAA)
-
PeptaNova
- (peptides) - including peptide substrates and
enzyme inhibitors
-
Peptides
International - (peptides, AA, UAA, resins, reagents)
-
Peptron
- (peptides) - caspase activity kits that use
peptide substrates
-
Phoenix
Peptides - (peptides) - specializing in
obesity and cardiovascular peptides, radioactive and fluorescent
peptides
-
Pi
Proteomics - (peptides, AA, UAA, resins, reagents)
-
Polymer
Laboratories - (resins) - wide range of
synthesis an scavenger resins including the StratoSpheres™ product line
- Polypeptide
Laboratories
- (AA, UAA, peptides)
- a large selection of unprotected and Boc, Fmoc, and Cbz protected
natural and unnatural amino acids including beta and gamma varieties
-
Polypeptides
- (peptides)
-
Protein
Tools - (peptides) - cytokines, growth
factors, and neurotrophins
-
Rapp
Polymere - (resins) - specializing in
TentaGelTM and polystyrene resins for SPOS and peptide synthesis
-
Reanal
Finechemical Private - (UAA, AA)
- manufactures and supplies protected amino acid derivatives with or
without carboxy-terminal activation in the range between hundred of
grams to hundred of kilos. Custom synthesis is also possible.
- RS
Synthesis -
(peptides, AA, UAA, resins)
-
Ryss
Laboratory - (UAA, resins)
-
Senn
Chemicals - (AA, UAA, peptides, reagents, resins)
- UAA include: UNCAs, Cbz-alpha-amino acids, and beta-amino acids
-
Shanghai
Hanhong Chemical Company - (AA, UAA, reagents)
- Shanghai
RD Biosciences - (AA, UAA, peptides)
-
Sigma-Aldrich
- (AA, UAA, peptides)
-
Silantes
- (UAA) - isotopically labeled amino acids for cell
cultivation
-
Sinopep
Pharmaceutical - (peptides)
- makers of bulk buserelin, calcitonin (salmon), desmopressin, glucagon
(human), gonadorelin, octreotide, oxytocin, somatostatin, thymosin a1,
and thymopentin
- Sussex
Research
- (UAA, AA)
-
specialists in glycopeptide and glycoamino acid synthesis .
They offer custom synthesis of glycopeptides and also manufacture a
large
selection of unprotected and Fmoc glycoamino acids.
-
Syd
Labs
- (AA, UAA, peptides, reagents, resins)
-
SynBioSci
Corporation - (AA, UAA, peptides, reagents, resins)
-
Synthetech
- (UAA, peptides, resins) - beta-amino acids, amino
alcohols, preloaded resins
-
Taitian
Chemicals - (AA, UAA, peptides, reagents, resins)
- a Chinese company that specializes in in amino acid derivatives and
specialty amino acids. They offer products on a gram to ton
scale
to customers following ISO 9001: 2000 international quality management
system guidelines.
-
Tianma
Pharma - (UAA, AA)
- a Chinese GMP manufacturer of unusual amino acids,
including Cbz, Boc, Fmoc amino acids and amino acid derivatives
- Titan -
(reagents)
- bulk and semi-bulk quantities of peptide synthesis reagents
-
Tocris
- (peptides)
-
Toronto
Research Chemicals - (UAA, AA)
-
Unibiochem
- (AA, UAA, peptides, reagents, resins) - protected
and unprotected
peptide fragments
-
USBiological
- ( peptides) - growth factors and cytokines
-
Wako
Chemicals - (peptides, AA, UAA)
-
Zhongbang
Pharma-Tech Company - (AA, UAA, resins)
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